聯(lián)系方式

郵箱：263276998@qq.com     

個(gè)人簡(jiǎn)介

1997.9-2001.7：東北師范大學(xué)化學(xué)學(xué)院，學(xué)士

2001.9-2004.7:東北師范大學(xué)化學(xué)學(xué)院，無(wú)機化學(xué)，碩士

2004.9-2007.7:中國科學(xué)院化學(xué)研究所，物理化學(xué)，博士

2007.7-2011.12:哈爾濱工業(yè)大學(xué)，生命科學(xué)與技術(shù)學(xué)院，講師

2012.1至今:哈爾濱工業(yè)大學(xué)，生命科學(xué)與技術(shù)學(xué)院，副教授

Personal Profile 

1997.9-2001.7,  School of Chemistry, Northeast Normal University, Bachelor

2001.9-2004.7, School of Chemistry, Northeast Normal University, Inorganic Chemistry, Master

2004.9-2007.7, Institute of Chemistry, Chinese Academy of Science, Physical chemistry, Doctor

2007.7-2011.12, School of Life Science and Technology, Institute of Technology, Lecture

2012.1 to present, School of Life Science and Technology, Institute of Technology, Associate Professor

研究方向和領(lǐng)域

生物傳感

Biosensors

納米診療試劑

Nano-theranostic agents

研究內容

1. 基于納米探針構建生物傳感器，用于檢測重金屬離子、農藥等環(huán)境污染物以及體液中與人體疾病相關(guān)的離子、分子標志物等生化物質(zhì)。

2. 構建具有聲、光、磁等多功能的造影劑，同時(shí)研究具有醫學(xué)診斷和治療作用的多功能診療一體化試劑。

Research Interests 

1. Developing biosensors based on nanoprobes for detecting various environmental pollutants such as heavy metal ions and pesticide residue as well as some biochemical substances such as ions and molecular markers in body fluids.

2. The construction of multi-functional contrast agents with ultrasound, light and magnetic properties, and the research of multi-functional theranostic agents with diagnostic and therapeutic effects.  

研究成果

1. Caixin Guo*, Jinliang Wang, Jing Cheng, Colorimetric sensing of copper (Ⅱ) ions based on the inhibition of biocatalytic growth of gold nanoparticles, Microchemical Journal 2020,157,105015.

2. Zhaohua Miao, Caixin Guo, Zhenglin Li, Yushen Jin, Hengte Ke, Zhifei Dai, Fabrication of a multimodal microbubble platform for magnetic resonance, ultrasound and fluorescence imaging application, Journal of Nanoscience and Nanotechnology, 2016, 16, 2301-2306.

3. Caixin Guo, Yushen Jin, and Zhifei Dai, Multifunctional ultrasound contrast agents for imaging guided photothermal therapy, Bioconjugate chem. 2014, 25, 840-854.

4. Xiuli Yue*, Caixin Guo, Yuanmiao Jing, Fang Ma, Free-standing liposomal nanohybrid cerasomes as ideal materials for cupric ions sensing, Analyst, 2012, 137, 2027-2031.

5. Caixin Guo, Jinliang Wang, Jing Cheng, Zhifei Dai, Determination of trace copper ions with ultrahigh sensitivity and selectivity utilizing CdTe quantum dots coupled with enzyme inhibition, Biosensor and Bioelectronics, 2012, 36, 69-74. （代表性成果）

6. Caixin Guo, Like Zeng, Shaoqin Liu, Qi Chen, Zhifei Dai, Xiaoyi Wu, In Vitro Evaluation and Finite Element Simulation of Drug Release from Polydiacetylene-Polyethylene Glycol Stearate Nanovesicles, J. Nanosci. Nanotech. 2012, 12, 245-251.

7. Caixin Guo, Jinliang Wang, Zhifei Dai, Selective content release from light-responsive microcapsules by tuning the surface plasmon resonance of gold nanorods, Microchimica Acta, 2011, 173, 375-382.（代表性成果）

8. Hengte Ke, Jinrui Wang, Zhifei Dai, Yushen Jin, Enze Qu, Zhanwen Xing, Caixin Guo, Xiuli Yue, Jibin Liu, Gold nanoshelled microcapsules: a theranostic agent for ultrasound contrast imaging and photothermal therapy, Angew. Chem. Int. Edit., 2011, 50, 3017-3021 (IF 13.455). Hot paper. Highlighted by Nature Materials.

9. Hengte Ke, Jinrui Wang, Zhifei Dai, Yushen Jin, Enze Qu, Zhanwen Xing, Caixin Guo, and Xiuli Yue, Bifunctional gold nanorod-loaded polymeric microcapsules for both contrast-enhanced ultrasound imaging and photothermal therapy, Journal of Materials Chemistry, 2011, 21, 5561-5564.

10. Caixin Guo, Shaoqin Liu, Zhifei Dai, Chang Jiang, Wenyuan Li, Polydiacetylene vesicles as a novel drug sustained-release system, Colloids and Surfaces B: Biointerfaces 2010, 76, 362-365.

11. Caixin Guo, Shaoqin Liu, Chang Jiang, Wenyuan Li, Zhifei Dai, Hiroe Fritz, Xiaoyi Wu, A Promising Drug Controlled-Release System Based on Diacetylene/Phospholipid Polymerized Vesicles, Langmuir 2009, 25, 13114-13119.（代表性成果）

12. Renzhe Zhang, Caixin Guo, Long Jiang, Tao Liu, The Fluorescence Recovery of Polydiacetylene/Fluorophore Vesicles by Interaction with Cetyltrimethylammonium Bromide，Journal of Nanoscience and Nanotechnology 2009, 9, 990-994.

13. Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, One-Step Immobilization of Dodecanethiol/Glycolipid Vesicles onto Gold Electrode: Amperometric Detection of Concanavalin A，Colloids and Surfaces B: Biointerfaces 2008, 62, 146-150.

14. Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, Highly Sensitive Gold Nanoparticles Biosensor Chips Modified with a Self-assembled Bilayer for Detection of Con A, Biosensor and Bioelectronics 2007, 22, 1830-1834.（代表性成果）

15. Caixin Guo, Paul Boullanger, Long Jiang, Tao Liu, Colorimetric Detection of WGA in Carbohydrate-functionalized Polydiacetylene Langmuir–Schaefer Films, Colloids and Surfaces A: Physicochem. Eng. Aspects 2007, 293, 152-156.

16. Caixin Guo, Renzhe Zhang, Long Jiang, Tao Liu，Investigation on the temperature effect of a mixed vesicle composed of polydiacetylene and BODIPY 558，Colloids and Surfaces B: Biointerfaces 2007, 60, 41–45.

17. Caixin Guo, Paul Boullanger, Tao Liu, Long Jiang, Size Effect of Polydiacetylene Vesicles Functionalized with Glycolipids on Their Colorimetric Detection Ability, J. Phys. Chem. B 2005, 109, 18765-18771.（代表性成果）

18. Caixin Guo, Minhua Cao, Changwen Hu, Synthesis and Characterization of Dy(OH)3 and Dy2O3 Nanotubes, J. Nanosci. Nanotech. 5, (2005), 184-187

19. Caixin Guo, Minhua Cao, Changwen Hu, A Novel and Low-temperature Hydrothermal Synthesis of SnO2 Nanorods, Inorg. Chem. Commun. 7, (2004), 929-931.

20. Minhua Cao, Caixin Guo, Yanjuan Qi, Changwen Hu, Enbo Wang, Shape and Size Control of ZnO Nanostructures via a Simple Solution Route, J. Nanosci. Nanotech. 4, (2004), 829-832.

21. Minhua Cao, Yonghui Wang, Caixin Guo, Yanjuan Qi, Changwen Hu, Enbo Wang, A simple route towards CuO nanowires and nanorods, J. Nanosci. Nanotech. 2004, 4 (7), 824-828.

22. Minhua Cao, Yonghui Wang, Caixin Guo, Yanjuan Qi, Changwen Hu, Preparation of ultrahigh-aspect-ratio hydroxyapatite nanofibers in reverse micelles under hydrothermal conditions, Langmuir, 2004, 20, 4784-4786.

23. Danfeng Li, Changzhi Gu, Caixin Guo, Changwen Hu, The effects of ambient gases on the surface resistance of polyoxometalate/TiO2 film, Chem. Phys. Lett., 2004, 385 (1-2), 55-59.

24. Yonghui Wang, Caixin Guo, Y. W. Chen, Changwen Hu, W. H. Yu, Self-assembled Multilayer Films Based on a Keggin-type Polyoxometalate and Polyaniline, J. Colloid and Interface Science, 264, (2003), 176.

專(zhuān)利 

郭彩欣，戴志飛，王金梁，成晶, 高靈敏度的銅離子檢測用熒光生物傳感器及其檢測方法, ZL201210085632.3.

開(kāi)設的課程

納米藥物學(xué)

Nanomedicine

生物醫學(xué)檢測及傳感器

Biomedical Detection and Sensor

 教師個(gè)人主頁(yè)鏈接

 http://homepage.hit.edu.cn/guocaixin