聯(lián)系方式
郵箱：hanfang@hit.edu.cn
個(gè)人簡(jiǎn)介
1996-2000年：東北農業(yè)大學(xué) 生物技術(shù) 學(xué)士
2000-2003年：東北農業(yè)大學(xué) 分子免疫學(xué) 碩士
2003-2006年：東北農業(yè)大學(xué) 分子遺傳學(xué) 博士
2015-2021年：哈爾濱工業(yè)大學(xué) 生命科學(xué)與技術(shù)學(xué)院 副教授
2011-2013年：美國A&M大學(xué)健康醫學(xué)中心 訪(fǎng)問(wèn)學(xué)者
Personal Profile
1996-2000: Bachelor of Biotechnology, Northeast Agricultural University
2000-2003: Master of Molecular Immunology, Northeast Agricultural University
2003-2006: Ph.D. in molecular genetics, Northeast Agricultural University
2015-2021: Associate Professor, School of Life Science and Technology, Harbin Institute of Technology
2011-2013: Visiting Scholar, A&M University Health Medical Center, USA
研究方向和領(lǐng)域
腫瘤細胞生物學(xué)
Tumor cell biology
腫瘤細胞糖代謝
Tumor cell glucose metabolism
研究內容
主要從事腫瘤細胞分子生物學(xué)、腸道微環(huán)境穩態(tài)調控機制、細胞的輻射損傷與修復和腫瘤診斷的分子標記物研究，實(shí)現生物醫學(xué)理論基礎研究技術(shù)轉化。
1.發(fā)現多功能蛋白MARVELD1：高度保守，影響細胞運動(dòng)遷移能力，影響小鼠出生后小腸發(fā)育以及功能細胞的分化和發(fā)育，調控DNA損傷與修復功能。
2.發(fā)現多功能蛋白MARVELD1影響腫瘤細胞糖代謝：研究腫瘤細胞葡萄糖代謝穩態(tài)失衡以及重編程過(guò)程的調控機制，并研究MARVELD1影響細胞葡萄糖代謝的分子機制。
3.應對新型冠狀病毒疫情，推進(jìn)醫工交叉，研發(fā)核酸檢測一體化設備與試劑，快速實(shí)現技術(shù)轉化。
Research Interests
Associate professor FANG HAN's research focuses on tumor cell biology, Tumor cell glucose metabolism, molecular diagnosis of diseases and the transformation of biomedical technology.
1. The research team found that the multifunctional protein MARVELD1 was highly conserved, affecting the movement and migration of cells, the differentiation and development of small intestine functional cells, and regulating DNA damage and repair functions.
2. The research team found that the multifunctional protein MARVELD1 affected glucose metabolism in tumor cells: Study the imbalance of glucose metabolism homeostasis and the regulation mechanism of reprogramming process in tumor cells; Study the molecular mechanism of MARVELD1 affecting glucose metabolism.
3. In response to the Novel Coronavirus outbreak, the research team have promoted the integration of medical and industrial, and developed integrated nucleic acid testing equipment and reagents, so as to achieve technological transformation.
研究成果
近五年內承擔或主持科研項目5項，其中包括：中國工程院防疫應急重大儀器研究項目、國家自然科學(xué)基金面上項目、黑龍江省自然科學(xué)基金面上項目、黑龍江省自然科學(xué)基金聯(lián)合引導項目等。近五年主要代表性科研論文：
1. PengDou,Yiqun Li, Haoxiu Sun, WanqiuXie, Xiaoqing Zhang, Xiaohan Zhang, Dandan Zhang, ShupeiQiao, Yanpeng Ci, HuanNie, Fang Han* and Yu Li* C1orf109L binding DHX9 promotes DNA damage depended on the R-loop accumulation and enhances camptothecinchemosensitivity，cell proliferation，dio：10.1111/cpr.12875. 2020.（并列通訊作者）
2. Chunbin Zhang, Fang Han, Ming Shi, Haoxiu Sun, Yiqun Li, Yanpeng Ci, Yuanfei Yao, Peng Dou, Muhammad luqman Akhtar, Huan Nie, Jie He, Li Y*. MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system. Mol Carcinog, 08;58(8):1410-1426, 2019.（并列第一作者）
3. Zongjun Liu, Tuo Li, Fang Han, You Wang,* Yang Gan,* Junhui Shi, Tianran Wang, Muhammad Luqman Akhtar, and Yu Li*.A Cascade-Reaction Enabled Synergistic Cancer Starvation/ROS-mediated /chemotherapy with Enzyme Modified Fe-based MOF. Biomater Sci,7(9): 3683-3692, 2019. （并列第一作者）
4. Weizhe Liu, Fang Han, Shuai Qu, Yuanfei Yao, Jianxiang Zhao, Muhammad Luqman Akhtar, Yanpeng Ci, Hao Zhang, Hongfei Li, Yufang Zhao, Lei Yue, Yao Zhang, Changlin Wang*&Yu Li*. MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell Death & Disease, 9: 999, 2018.
5. Chen Y, Zhang H, Han F, Yue L, Qiao C, Zhang Y, Dou P, Liu W, Li Y. The depletion of MARVELD1 leads to murine placenta accreta via integrin β4-dependent trophoblast cell invasion. J Cell Physiol, 2018, 233(3): 2257-2269
開(kāi)設的課程
免疫學(xué)
Immunology
分子免疫學(xué)
Molecular Immunology
生命科學(xué)基礎與應用
Fundamentals and Applications of Life Sciences
教師個(gè)人主頁(yè)鏈接
http://homepage.hit.edu.cn/FANGHAN
