聯(lián)系方式
郵箱：fanyang115@hit.edu.cn
個(gè)人簡(jiǎn)介
2000-2004年：南開(kāi)大學(xué) 化學(xué)專(zhuān)業(yè)理學(xué)學(xué)士
2004-2009年：北京大學(xué) 物理化學(xué)專(zhuān)業(yè)理學(xué)博士
2009-2013年：美國華盛頓大學(xué) 化學(xué)學(xué)院博士后
2013-2017年：美國華盛頓大學(xué) 化學(xué)學(xué)院研究助理/代理講師
2017-至今：哈爾濱工業(yè)大學(xué) 生命科學(xué)與技術(shù)學(xué)院副研究員
研究方向和領(lǐng)域
液體核磁共振研究生物大分子相互作用的分子機制
Exploring the molecular basis of RNA recognition by RNP by using solution NMR
研究?jì)热?/span>
1. 不同RNA結合蛋白對microRNA生成過(guò)程調控的結構基礎；
2. RRM和zinc finger等RNA結合結構域的理性設計；
3. mRNA前體3’末端加工過(guò)程相關(guān)蛋白因子與PAS RNA的相互作用關(guān)系。
Research Interests
1. The structural basis of the regulation of microRNA processing by protein factors;
2. Engineering RNA-binding proteins and understanding protein-RNA recognition specificity;
3. Structural relationship within protein factors involved in pre-mRNA 3’-end processing.
研究成果
1. Fan Yang, Peter Hsu, Susan Lee, Wen Yang, Derick Hoskinson, Weihao Xu, Claire Moore, Gabriele Varani*. The C-terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3’-end processing. RNA 23 (1), 98-107, 2017.
2. 2. Yu Chen?, Lorena Zubovic?, Fan Yang?, Katherine Godin, Tom Pavelitz, Javier Castellanos, Paolo Macchi*, Gabriele Varani*. Rbfox proteins regulate microRNA biogenesis by sequence specific binding to their precursors and target downstream Dicer. Nucleic Acids Research 44 (9), 4381-4395, 2016.? co-first authors.
3. 3. Yu Chen, Fan Yang, Lorena Zubovic, Tom Pavelitz, Wen Yang, Katherine Godin, Suxin Zheng, Paolo Macchi, Gabriele Varani*. Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins. Nature Chemical Biology 12 (9), 717-723, 2016.
4. 4. Wen Yang?, Peter L. Hsu?, Fan Yang, Jae-Eun Song, Gabriele Varani*. Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in its recognition of 3’-end processing signals. Nucleic Acids Research 46 (2), 493-503, 2018.*NAR Breakthrough Article
5. 5. Maria L. Romero Romero, Fan Yang, Yu-Ru Lin, Agnes Toth-Petroczy, Igor N. Berezovsky, Alexander Goncearenco, Wen Yang, Alon Wellner, Fanindra Kumar-Deshmukh, Michal Sharon, David Baker, Gabriele Varani, and Dan S. Tawfik*. Simple yet functional phosphate-loop proteins. Proceedings of the National Academy of Sciences 115 (51), E11943-E11950, 2018.
6. 6. Corey M Nemec, Fan Yang, Joshua M. Gilmore, Corinna Hintermair, Yi-Hsuan Ho, Sandra C. Tseng, Martin Heidemann, Ying Zhang, Laurence Florens, Audrey P. Gasch, Dirk Eick, Michael P. Washburn, Gabriele Varani, and Aseem Z. Ansaria*. Different phospho-isoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner. Proceedings of the National Academy of Sciences 114 (20), E3944-E3953, 2017.
7. 7. Ravi P. Barnwal, Fan Yang, and Gabriele Varani*. Applications of NMR to structure determination of RNAs large and small. Archives of Biochemistry and Biophysics 628, 42-56, 2017.
8 8. Anna Bochicchio, Miroslav Krepl*, Fan Yang, Gabriele Varani, Jiri Sponer, Paolo Carloni*. Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study. PLOS Computational Biology 14 (12), e1006642, 2018.
開(kāi)設的課程
工程倫理
Engineering Ethics
細胞中的社交網(wǎng)絡(luò )-生物大分子相互作用
Inter-biomolecular Social Networking
教師個(gè)人主頁(yè)鏈接
http://homepage.hit.edu.cn/fanyang
