聯(lián)系方式

郵箱：wangcl@hit.edu.cn

個(gè)人簡(jiǎn)介

2000-2004年：蘭州大學(xué) 理學(xué)學(xué)士

2004-2009年：蘭州大學(xué) 理學(xué)博士

2009-2012年：哈爾濱工業(yè)大學(xué) 講師

2012-2021年：哈爾濱工業(yè)大學(xué) 副教授

2022年-至今：哈爾濱工業(yè)大學(xué) 教授 

Personal Profile

B.Sc. in Biological Science, 2004, School of Life Science, Lanzhou University, China   

Ph.D. in Biochemistry and Molecular Biology, 2009, School of Life Science, Lanzhou University, China 

Lecturer, School of Life Science and Technology, Harbin Institute of Technology, China, 2009-2012

Associate Professor, Master's Supervisor, School of Life Science and Technology, Harbin Institute of Technology, China, 2012-2021

Professor, Doctoral Supervisor, School of Life Science and Technology, Harbin Institute of Technology, China, 2022-present

研究方向和領(lǐng)域

神經(jīng)多肽藥物構效關(guān)系與活性研究

Structure-Activity Study of Neuropeptides

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神經(jīng)多肽藥物藥理學(xué)與行為學(xué)活性研究

Neuropeptides Physiology & Pharmacology

內嗎啡肽的結構改造與阿片活性研究

Structure-Activity Study of Endomorphins and their opioid activities

研究成果

1.  Yu-zhe Zhang, Meng-meng Wang, Si-yu Wang, Xiao-fang Wang, Wen-jiao Yang, Ya-nan Zhao, Feng-tong Han, Yao Zhang, Ning Gu*, Chang-lin Wang* Novel cyclic endomorphin analogs with multiple modifications and oligoarginine-vector exhibit potent antinociception with reduced opioid-like side effects. Journal of Medicinal Chemistry, 64: 16801-16819, 2021.

2.  Zhang YZ, Yang WJ, Wang XF, Wang MM, Zhang Y, Gu N*, Wang CL*, The spinal anti-allodynic effects of endomorphin analogs with C-terminal hydrazide modification in neuropathic pain model. Peptides 2020;134:170407.

3. Wang CL^*, Yang DJ, Yuan BY, Wang Y.C-terminal hydrazide modification changes the spinal antinociceptive profiles of endomorphins in mice. Peptides 2018;99:128-133.

4. Yuan BY, Liu WZ, Wang XF, Zhang YZ, Yang DJ,Wang CL^*. Endomorphin-1 analogs with oligoarginine-conjugation at C-terminus produce potent antinociception with reduced opioid tolerance in paw withdrawal test. Peptides 2018;106:96-101.

5. Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y, Wang CL^*, Li Y^*. MARVELD1 depletion leads to dysfunction of motor and cognition via regulating gliadependent neuronal migration during brain development. Cell Death and Disease 2018;9:999.

6. Wang CL^*, Qiu TT, Yang DJ, Yuan BY, Han FT, Li L, Gu N. Endomorphin-2 analogs with C-terminal esterification produce potent systemic antinociception with reduced tolerance and gastrointestinal side effects. Neuropharmacology 2017;116:98-109.

7. Wang CL^*, Yang DJ, Yuan BY, Qiu TT. Antiallodynic Effects of Endomorphin-1 and Endomorphin-2 in the Spared Nerve Injury Model of Neuropathic Pain in Mice. Anesth. Analg., 2017;125:2123-2133.

8. Wang CL^*, Qiu TT, Diao YX, Zhang Y, Gu N. Novel endomorphin-1 analogs with C-terminal oligoarginine-conjugation display systemic antinociceptive activity with less gastrointestinal side effects. Biochimie 2015 ;116:24-33.

9. Wang CL^*, Xiang Q, Diao YX, Ren YK, Gu N. Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogs in mice. Eur. J. Pain 2014;18:1157-1164.

10. Wang CL^*, Diao YX, Xiang Q, Ren YK, Gu N.Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice  Eur. J. Pharmacol.2014;738:1-7.

11. Wang CL^*, Ren YK, Xiang Q, Wang Y, Gu N, Lu C, Wang R^*. Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. Neuropeptides 2013;47:297-304.

12. Wang CL^*, Zhou Y, Guo C, Zhang Y, Wang R^*. In vivo characterization of intestinal effects of endomorphin-1 and endomorphin-2 in type 1 diabetic mice. Eur. J. Pharmacol. 2013;698:499-504.

13. 王長(cháng)林，張雨哲，袁碧玉. 強啡肽A(1-8)與神經(jīng)降壓素(8-13)相偶聯(lián)的環(huán)化雜合肽及其合成方法和應用，授權公告日：2019.6.11，中國發(fā)明專(zhuān)利，專(zhuān)利號：201811126681.0

14. 王長(cháng)林，張雨哲，袁碧玉. 多位點(diǎn)修飾的腦啡肽與神經(jīng)降壓素(8-13)相偶聯(lián)的環(huán)化雜合肽及其合成方法和應用，授權公告日：2019.6.11，中國發(fā)明專(zhuān)利，專(zhuān)利號：201811125677.2

15. 王長(cháng)林，袁碧玉，楊代軍. 基于內嗎啡肽-1和神經(jīng)降壓素(8-13)的嵌合肽及其合成方法和應用, 授權公告日：2018.11.02，中國發(fā)明專(zhuān)利，專(zhuān)利號：201711365284.4

16. 王長(cháng)林，袁碧玉，楊代軍.4位苯丙酰胺羥基化修飾的內嗎啡肽類(lèi)似物及其合成方法和應用, 授權公告日：2018.10.02，中國發(fā)明專(zhuān)利，專(zhuān)利號：201711367596.9

17. 王長(cháng)林，楊代軍，袁碧玉. C-末端芳香酯化修飾的內嗎啡肽-1類(lèi)似物及其合成和應用, 授權公告日：2018.12.11，中國發(fā)明專(zhuān)利，專(zhuān)利號：201711366704.0

開(kāi)設的課程

生命科學(xué)導論(文化素質(zhì)選修課)

Introduction of Life Science

人體生理學(xué)(研究生專(zhuān)業(yè)課)

Human Physiology

神經(jīng)生物學(xué)(本科生專(zhuān)業(yè)課)

Neurobiology

具有鎮痛價(jià)值的新型內嗎啡肽類(lèi)似物的阿片生物學(xué)活性實(shí)驗(本科生創(chuàng )新實(shí)驗課)

Experiments of Opioid Bioactivities of Novel Endomorphin Analogs with Antinociceptive Effects

教師個(gè)人主頁(yè)鏈接

http://homepage.hit.edu.cn/shuangmu