聯(lián)系方式        

郵箱：nh1212@hit.edu.cn    

個(gè)人簡(jiǎn)介

1996-2000年：哈爾濱師范大學(xué) 生物工程學(xué)士

2000-2003年：哈爾濱師范大學(xué) 遺傳學(xué)碩士

2003-2006年：中國農業(yè)大學(xué) 生物學(xué)與生物化學(xué)博士

2006-2008年：哈爾濱工業(yè)大學(xué) 講師

2008-2017年：哈爾濱工業(yè)大學(xué) 副教授

2017 -    年：哈爾濱工業(yè)大學(xué) 教授

Personal Profile

1996-2000：Harbin Normal University, Bachelor of Bioengineering

2000-2003：Harbin Normal University, Master of Genetics

2003-2006：China Agricultural University, PhD in Biology and Biochemistry

2006-2008：Harbin Institute of Technology, Lecturer

2008-2017：Harbin Institute of Technology,  Associate Professor

Since 2017：Harbin Institute of Technology,  Professor

研究方向和領(lǐng)域

癌癥糖生物學(xué)

Cancer Glycobiology

癌癥代謝生物學(xué)

Cancer Metabolic Biology

研究?jì)热?/span>

一直從事癌癥糖生物學(xué)和代謝生物學(xué)的基礎研究工作。作為黑龍江省優(yōu)秀研究生團隊和哈工大創(chuàng )新團隊的成員，從血清、體外培養細胞和組織多個(gè)層面研究癌癥特異改變的糖鏈分子和小分子代謝物，并深入探討其發(fā)生改變的分子機制。

Research Interests 

Professor Nie has been engaged in the basic research on glycobiology and metabolic biology of cancer. As a member of the outstanding postgraduate team of Heilongjiang Province and the innovation team of Harbin Institute of Technology, he studies cancer-specifically altered glycan chain molecules and small molecular metabolites from multiple levels of serum, cultured cells and tissues in vitro, and deeply explores the molecular mechanisms of their changes.

研究成果 

1.    Xiaoqing Zhang, Peng Dou, Muhammad Luqman Akhtar, Fei Liu, Xibo Hu, Lijun Yang, Depeng Yang1, Xiaohan Zhang, Yiqun Li, Shupei Qiao, Kai Li, Ran Tang, Chao Zhan, Yue Ma, Qixiang Cheng, Fang Han, Huan Nie*, Yu Li*. NEU4 inhibits motility of HCC cells by cleaving sialic acids on CD44. Oncogene. DOI : 10.1038/s41388-021-01955-7

2.   Pingping Wang, Xiyun Jin, Wenyang Zhou, Meng Luo, Zhaochun Xu, Chang Xu, Yiqun Li, Kexin Ma, Huimin Cao, Yan Huang, Guangfu Xue, Huan Nie*, Qinghua Jiang*.Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing. Genomics. 2021 Mar;113(2):456-462.

3.     Depeng Yang, Lijun Yang, Jialing Cai, Xibo Hu, Huaxin Li, Xiaoqing Zhang, Xiaohan Zhang, Xinghe Chen, Haiyang Dong, Huan Nie*, Yu Li*.  A sweet spot for macrophages: Focusing on polarization. Pharmacological Research.2021, 167,105576. 

4.    Chunbo Wang, Depeng Yang, Xiaoqing Zhang, Xiaohan Zhang, Lijun Yang, Pingping Wang, Wenyang Zhou, Huaxin Li, Yiqun Li, Huan Nie*, Yu Li*.  Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy. Front Genet. 2020 Apr 23;11:298.

5.    Wenyang Zhou, Fan Yang, Zhaochun Xu, Meng Luo, Pingping Wang, Yu Guo, Huan Nie*, Lifen Yao*, Qinghua   Jiang*. Comprehensive Analysis of Copy Number Variations in Kidney Cancer by Single-Cell Exome Sequencing . Front Genet. 2019; 10: 1379.

6.     Zhang X, Nie H, Whited J, Wang D, Li Y, Sun XL. Recent approaches for directly profiling cell surface sialoform. Glycobiology. 2018 Dec 1;28(12):910-924.

7.     Zhang Xiaohan, Shi Xiuyun, Lu Xin, Bai Yunfan, Li Yiqun, Zhao Jianxiang, Zhang Xiaoqing, Akhtar Muhammad Luqman, Wang Yu, Yao Yuanfei, Li Yu*, Nie Huan*. Novel metabolomics serum biomarkers for Pancreatic Ductal Adenocarcinoma by the comparison of pre-, postoperative and normal samples. Journal of Cancer, 2020, 19;11(16):4641-4651.

8.    Xin Lu, Xiaohan Zhang,Yongjian Zhang, Kun Zhang, Chao Zhan, Xiuyun Shi, Yiqun Li, Jianxiang Zhao, Yunfan Bai, Yu Wang, Huan Nie*，Yu Li*. Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2. Mol Carcinog. 2019,58(5):749-759.

9.    Wang C#, Nie H#, Li Y, Liu G1, Wang X, Xing S, Zhang L, Chen X, Chen Y, Li Y. The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC. Sci Rep. 2016 Jun 1;6:26526.

10.   Xin Lu, Huan Nie, Yiqun Li, Chao Zhan, Xia Liu, Xiuyun Shi,Ming Shi, Yubao Zhang,Yu Li. Comprehensive Characterization and Evaluation of Hepatocellular Carcinoma by LC-MS Based Serum. Metabolomics, 2015, 11(5):1381-1393 

11.   Huan Nie, Xia Liu, Yubao Zhang, Tingting Li, Chao Zhan, Wenjuan Huo, Anshun He, Yuanfei Yao, Yu Jin,  Youpeng Qu, Xue-Long Sun, Yu Li. Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyl transferases-IVa Regulation. Sci Rep. 2015; 5: 16007.

12.    Narla SN, Nie H, Li Y, Sun XL. Multi-dimensional glycan microarrays with glyco-macroligands. Glycoconj J.   2015 Oct;32(7):483-95.

13.    Wang D, Nie H, Ozhegov E, Wang L, Zhou A, Li Y, Sun XL. Globally profiling sialylation status of macrophages upon statin treatment. Glycobiology. 2015 Sep;25(9):1007-15.

14.   Xia Liu, Huan Nie, Yubao Zhang, Yuanfei Yao, Alaiyi Maitikabili, Youpeng Qu, Shuliang Shi, Cuiying Chen,   and Yu Li, Cell Surface-Specific N-Glycan Profiling in Breast Cancer, Plos One, 2013; 8 (8): e72704. 

15.   Nie Huan, Yao Yuanfei, Ding Ning, Liu Xia, Qu Youpeng, Li Yu.The N-Glycomic research on the Serum   Biomarkers of Breast Cancer. Clinical and Experimental Pharmacoogy and Physiology. 2013; （40）, Issue   Supplement s1, 16 2.004

16.   Huan Nie, Yu Li, Xue-Long Sun. Recent Advances in Sialic Acid-Focused Glycomics. Journal of Proteomics.   2012; 75(11):3098-3112,

17.    Ding N, Nie H, Sun X, Sun W, Qu Y, Liu X, Yao Y, Liang X, Chen CC, Li Y. Human Serum N-Glycan Profiles      Are Age and Sex Dependent. Age Ageing. 2011; 40(5):568-75.

18.   Satya Nandana Narla, Huan Nie, Yu Li, Xue-Long Sun. Recent Advances in the Synthesis and Biomedical       Applications of Chain-End Functionalized Glycopolymers. Journ al of Carbohydrate Chemistry, 2012; 31(2):67-   92

19.   Yang J, Nie H, Chen L, Zhang X, Yang F, Xu X, Zhu Y, Yu J, Jin Q. Revisiting the Molecular Evolutionary   History of Shigella spp. J Mol Evol. 2007; 64(1):71-9

20.    Nie H, Yang F, Zhang X, Yang J,et al. Complete genome sequence of Shigella flexneri 5b and comparison with   Shigella flexneri 2a. BMC Genomics. 2006; 7:173.

21.   Liu W, Nie H, Wang S, et al. Mapping a resistance gene in wheat cultivar Yangfu 9311 to yellow mosaic virus,   using microsatellite markers. Theor Appl Genet. 2005; 111(4):651-7.

22.   Wei-Hua LIU, Huan NIE, Zhen-Tian HE, Xiu-Lan CHEN, et al..Mapping of a Wheat Resistance Gene to Yellow   Mosaic Disease by Amplified Fragment Length Polymorphism and Simple Sequence Repeat Markers. Journal of   Integrative Plant Biology 2005; 47 (9): 1133－1139

開(kāi)設的課程

生物化學(xué)A（2） 

BiochemistryA(2)

生命科學(xué)基礎與應用 

Fundamentals and applications of Life Sciences

生物大分子結構與功能  

Structure and function of biological macromolecules

教師個(gè)人主頁(yè)鏈接

http://homepage.hit.edu.cn/niehuan