聯(lián)系方式    

郵箱：huangzhiwei@hit.edu.cn 

個(gè)人簡(jiǎn)介

哈工大生命科學(xué)與技術(shù)學(xué)院教授、院長(cháng)，生命科學(xué)中心主任。

2008年從北京生命科學(xué)研究所柴繼杰教授結構生物學(xué)實(shí)驗室博士畢業(yè)，

然后去哈佛大學(xué)免疫與感染疾病系 Laurie H. Glimcher教授免疫學(xué)實(shí)驗室做博士后，

2012年回國到哈工大建立實(shí)驗室，研究微生物和人適應性免疫的分子機制，以及新型基因編輯工具的開(kāi)發(fā)。

Personal Profile

Prof. Huang is dean of the School of Life Science and Technology 

and director of HIT Center for Life Sciences at Harbin Institute of Technology. 

After finishing his PhD thesis from the structural biology of Dr. Jijie Chai 

at National Institute of Biological Sciences in 2008, 

he then went to the immunological lab of Dr. Laurie H. Glimcher 

at Harvard University to receive his postdoctoral training. 

In March 2012, he joined the School and Life Science and Technology at Harbin Institute of Technology as a professor. 

His research mainly focuses on studying the molecular mechanisms of bacterial and human adaptive immune systems and developing novel genome editting tools.

研究方向和領(lǐng)域

采用整合的研究方法包括生物信息學(xué)、病毒學(xué)、免疫學(xué)、結構生物學(xué)以及小鼠遺傳學(xué)等，從分子、細胞以及個(gè)體水平等多個(gè)層次以較全視野對適應性免疫系統以及病毒拮抗機制進(jìn)行研究。研究方向包括：

1. 研究人適應性免疫系統以及病毒拮抗宿主免疫的功能與機制。

2. 研究細菌CRISPR-Cas系統以及噬菌體Anti-CRISPR系統的分子機制,同時(shí)基于研究成果靶向設計高效的、特異性的新型基因編輯工具。

3. 研究在生理和病理過(guò)程中人微生態(tài)系統中病毒、細菌的功能與機制。

4. 解析免疫與感染性疾病發(fā)生過(guò)程中起關(guān)鍵作用的蛋白（復合物）的分子機制，并利用這些結構信息理性設計小分子藥物治療相關(guān)疾病。

Research Area

We use multi-disciplinary approaches including bioinformatics, single cell sequencing, immunology, structural biology, and mouse models from to study the molecular mechanisms of microbe and human adaptive immune systems, microbial dysbiosis in human diseases, how immune systems interaction with other systems in the body, and developing novel CRISPR-Cas genome editing tools for the treatment of genetic disorders.

研究成果

1.      Hongnan Liu*, Yuwei Zhu*, Zebin Lu, Zhiwei Huang# (2021). Structural basis of Staphylococcus aureus Cas9 inhibition by AcrIIA14. Nucleic Acids Res. 21;49(11):6587-6595.

2.      Xianwen Ren*, Wen Wen*, Xiaoying Fan*, Wenhong Hou*, Bin Su*, Pengfei Cai*, Jiesheng Li*, Yang Liu*, Fei Tang*, Fan Zhang*, Yu Yang*……Zhiwei Huang#, Jin-Xin Bei#, Lai Wei#, Xiu-Wu Bian#, Xindong Liu#, Tao Cheng#, Xiangpan Li#, Pingsen Zhao#, Fu-Sheng Wang#, Hongyang Wang#, Bing Su#, Zheng Zhang#, Kun Qu#, Xiaoqun Wang#, Jiekai Chen#, Ronghua Jin#, Zemin Zhang# (2021). COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 184(7):1895-1913.

3.      Shengli Ma*#, Fan Zhang*, Fengxia Zhou*, Hui Li*, Wenyu Ge, Rui Gan, Huan Nie, Biao Li, Yindong Wang, Meng Wu, Duo Li, Dongmei Wang, Zheng Wang, and Yuhong You, Zhiwei Huang# (2021). Metagenomic analysis reveals throat microbiota alterations in patients with COVID-19. Signal Transduction Targeted Therapy. 6, 191.

4.      Fan Zhang*, Rui Gan*, Ziqi Zhen*, Xiaoli Hu*, Xiang Li, Fengxia Zhou, Ying Liu, Chuangeng Chen, Shuangyu Xie, Bailing Zhang, Xiaoke Wu, Zhiwei Huang# (2020). Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals. Signal Transduction Targeted Therapy. 5(1):156.

5.      Kaiming Zhang*, Shuo Wang*, Sahnshan Li*, Yuwei Zhu*, Grigore D. Pintilie, Tung-Chung Mou, Michael F. Schmid, Zhiwei Huang# & Wah Chiu# (2020). Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas. PNAS. 117(13):7176-7182.

6.      De Dong*, Lvqin Zheng*, Jianquan Lin*, Bailing Zhang, Yuwei Zhu, Ningning Li, Shuangyu Xie, Yuhang Wang, Ning Gao#, Zhiwei Huang# (2019). Structural basis of assembly of the human T cell receptor-CD3 complex. Nature. 573(7775):546-552. (This paper is featured with News & Views, Nature. 573, 502-504 (2019))

7.      Liyong Dong*, Xiaoyu Guan*, Ningning Li*, Fan Zhang, Yuwei Zhu, Kuan Ren, Ling Yu, Fengxia Zhou, Zhifu Han, Ning Gao & Zhiwei Huang# (2019). An anti-CRISPR protein disables type V Cas12a by acetylation. Nature Structural & Molecular Biology. 26(4):308-314.

8.      Minghui Guo*, Kaiming Zhang*, Yuwei Zhu, Grigore D. Pintilie, Xiaoyu Guan, Shanshan Li, Michael F. Schmid, Zhuo Ma, Wah Chiu# & Zhiwei Huang# (2019). Coupling of ssRNA Cleavage with DNase Activity in Type III-A CRISPR-Csm Revealed by Cryo-EM and Biochemistry. Cell Research. 29(4):305-312

9.      Minghui Guo*, Kuan Ren*, Yuwei Zhu*, Ziyun Tang, Yuhang Wang, Bailing Zhang & Zhiwei Huang# (2019). Structural insights into a high fidelity variant of SpCas9. Cell Research. 29,183-192.

10.  Yuwei Zhu, Zhiwei Huang# (2018). Recent advances in structural studies of the CRISPR-Cas-mediated genome editing tools. National Science Review. doi: 10.1093/nsr/nwy150

11.  Fan Zhang*#, Shijia Zhao*, Chunyan Ren*, Yuwei Zhu, Haibin Zhou, Yongkui Lai, Fengxia Zhou, Yuqiang Jia, Kangjie Zheng & Zhiwei Huang# (2018). CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions. Communications Biology. 31;1:180.

12.  De Dong*, Minghui Guo*, Sihan Wang*, Yuwei Zhu, Shuo Wang,Zhi Xiong, Jianzheng Yang, Zengliang Xu and Zhiwei Huang# (2017). Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. Nature. 546(7658):436-439.

13.  Dan Wu*, Xiaoyu Guan*, Yuwei Zhu*, Kuan Ren, Zhiwei Huang# (2017). Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA. Cell Research. 27(5):705-708.

14.  Pu Gao, Hui Yang, Kanagalaghatta R Rajashankar, Zhiwei Huang and Dinshaw J Patel (2016). Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Research. 26(8):901-13.

15.  De Dong*, Kuan Ren*, Xiaolin Qiu*, Jianlin Zheng, Minghui Guo, Xiaoyu Guan, Hongnan Liu, Ningning Li, Bailing Zhang, Daijun Yang, Chuang Ma, Shuo Wang, Dan Wu, Yunfeng Ma, Shilong Fan, Jiawei Wang, Ning Gao and Zhiwei Huang# (2016). Crystal structure of CRISPR-Cpf1 in complex with CRISPR RNA (crRNA). Nature. 532(7600):522-6.

16.  Yingying Guo*, Liyong Dong*, Xiaolin Qiu*, Yishu Wang, Bailing Zhang, Hongnan Liu, You Yu, Yi Zang, Maojun Yang and Zhiwei Huang# (2014). Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif. Nature. 505(7482):229-33. (This paper is featured with News & Views, Nature. 505, 167-168, highlighted in Nature Structural & Molecular Biology, 21, 117 (2014))

17.  Jae-Hyuck Shim, Matthew B. Greenblatt, Weiguo Zou, Zhiwei Huang, Marc N. Wein, Nicholas Brady, Dorothy Hu, Jean Charron, Heather R. Brodkin, Gregory A. Petsko, Dennis Zaller, Bo Zhai, Steven Gygi, Laurie H. Glimcher and Dallas C. Jones (2013). Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123(9):4010-22.

18.  Zehan Hu, Chuangye Yan, Peiyuan Liu, Zhiwei Huang, Rui Ma, Chenlu Zhang, Ruiyong Wang, Yueteng Zhang, Fabio Martinon, Di Miao, Haiteng Deng, Jiawei Wang, Junbiao Chang, Jijie Chai (2013). Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 341(6142):172-5.

19.  Weiguo Zou, Xi Chen, Jae Shim, Zhiwei Huang, Nicholas Brady, Dorothy Hu, Rebecca Drapp, Kirsten Sigrist, Laurie H. Glimcher, Dallas Jones (2011). The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13(1):59-65.

20.  Zhiwei Huang*, Sarah E. Sutton*, Adam J. Wallenfang, Robert C. Orchard, Xiaojing Wu, Yingcai Feng, Jijie Chai and Neal M. Alto (2009). Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics. Nature Structural & Molecular Biology. 16(8):853-60. (This publication was selected as cover story, and high-lighted by Nature China）

21.  Zhiwei Huang, Yingcai Feng, Ding Chen, Xiaojing Wu, Xiaojun Wang, Xingguo Xiao, Wenhui Li, Niu Huang, Lichuan Gu, Guangming Zhong and Jijie Chai (2008). Structural basis for activation and inhibition of the secreted chlamydia protease CPAF. Cell Host & Microbe. 4(6):529-42. (This publication was selected as a research “highlight” by Nature China）

22.  Maikke B. Ohlson, Zhiwei Huang, Neal M. Alto, Jack E. Dixon, Jijie Chai and Samuel I. Miller (2008). Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation. Cell Host & Microbe. 4(5):434-46.

榮譽(yù)稱(chēng)號

科學(xué)探索獎，2020

國家高層次人才計劃，2018

國家杰出青年科學(xué)基金，2018

談家楨生命科學(xué)創(chuàng )新獎，2018

中國青年科技獎，2018

國家高層次青年人才計劃，2015

國家優(yōu)秀青年科學(xué)基金，2014

黑龍江省杰出青年科學(xué)基金，2014

開(kāi)設的課程

結構生物學(xué)概論

Introduction to Structural Biology

生物專(zhuān)業(yè)導論

Introduction to Biology

生命BIO-X導論

Introduction of BIO-X

結構分子生物學(xué)

Structural Molecular Biology

教師個(gè)人主頁(yè)鏈接

http://homepage.hit.edu.cn/huangzhiwei