1999-2002年：復旦大學(xué)（原上海醫科大學(xué)）生物化學(xué)與分子生物學(xué) 碩士

2002-2004年：香港中文大學(xué)臨床腫瘤學(xué) 碩士

2004-2009年：倫敦大學(xué)大學(xué)學(xué)院腫瘤學(xué) 博士

2009-2011年：牛津大學(xué) Ludiwig腫瘤研究所 博士后

2012-今：哈爾濱工業(yè)大學(xué)  教授  博導

Personal Profile 

1994-1999: Shandong Medical University   Bachelor in Public Health   

1999-2002：Fudan University     Master in Biochemistry and molecular biology  

2002-2004: The Chinese University of HongKong    Master in Clinical Oncology   

2004-2009: University College London   PhD in cancer biology 

2009-2011: Oxford University     Postdoctoral Biologist

2012-    : Harbin Institute of Technology    Professor 

研究方向和領(lǐng)域

腫瘤生物學(xué)

Cancer Biology

研究?jì)热?/span>

  耐藥和轉移是導致腫瘤患者不良預后的重要原因，“腫瘤基因功能研究團隊” 綜合利用細胞生物學(xué)，生物化學(xué)，分子生物學(xué)等研究方法，以小鼠為主要動(dòng)物模型，結合腫瘤患者標本檢測和相關(guān)信息分析展開(kāi)以下研究，為提高腫瘤的治療效果提供線(xiàn)索，為抑制腫瘤的轉移提供新的解釋和分子靶點(diǎn)。

1. 包括長(cháng)鏈非編碼RNA在內的癌基因以及抑癌基因的活化機制及功能研究

2. 腫瘤與微環(huán)境的互作機制研究

Research Interests

    Prof. Hu leads the tumor gene function study group with a focus on novel targets that modulate mechanisms of drug resistance and cancer metastasis, the leading reasons for the resultant mortality of patients with cancer. The group currently uses a combination of cellular and molecular strategies, animal tumor models and human samples to work on the following specific issues in the field:

1. The activation and function of oncogenes, as exampled by ASPP family proteins

2. The roles and mechanisms of long non coding RNA (lncRNA) in cancer

3. The interconnection between tumor cell and tumor microenvironment

研究成果

1. Xingwen Wang, Dong Zhao, Hui Xie, Ying Hu*. Interplay of long non-coding RNAs and HIF-1α: A new dimension to understanding hypoxia-regulated tumor growth and metastasis. Cancer Lett. 2021 Feb 28;499:49-59.

2. Kunming Zhao, Ying Hu*. Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment. Signal Transduct Target Ther. 2020 Jul 29;5(1):136.

3. Xingwen Wang, Yudong Wang, Li Li, Xuting Xue, Hui Xie, Huaxing Shi and Ying Hu*. A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia. Oncogene. 2020 Feb;39(9):1860-1874. Epub 2019 Nov 29.

4. Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. PLos Biol. 2020 Mar 23;18(3):e3000666.

5. Huayi Li#, Wenxin Zhang#, Kunming Zhao, Dong Zhao, Shanliang Zheng, Ying Hu*. A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. J Biol Chem. 2020 Mar 20;295(12):4049-4063. Epub 2020 Jan 31.

6. Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Qiong Wu, Ying Hu*. A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth. Cell Death Differ. 2020 Apr;27(4):1431-1446. Epub 2019 Nov 7. CDDPress Monthly Top Picks

7. Huyi Li#, Xingwen Wang#, Cheng Zhang, Yiwei Cheng, Miao Yu, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han, Hu Ying*. HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma. Cancer Lett. 2018 Jun 8;432:121-131. 8. Wenjie Ge#, Kunming Zhao#,Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Zhang, Yiwei Cheng, Shijian Jiang, Ying Hu*. iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 binding. Cancer Cell. 2017 Nov 13;32(5):561-573. Epub 2017 Oct 12. Featured article

9. Wang Xingwen, Cheng Yiwei, Zhu Yifu, Li Huayi, Ge Wenjie, Wu Xiaoliang, Zhao Kunming, Yuan J, Li Z, Jiang S, Han Zhengbin, Jiang Qinghua, Wu Qiong, Liu Tao, Zhang Cheng*, Yu Miao*, Hu Ying*. Epigenetic Silencing of ASPP1 confers 5-FU resistance in Clear Cell Renal Cell Carcinoma by preventing p53 activation. Int J Cancer. 2017 Oct 1;141(7):1422-1433. doi: 10.1002/ijc.30852. Epub 2017 Jul 10.

10. Kunming Zhao, Miao Yu, Yifu Zhu, Dong Liu, Qiong Wu, and Ying Hu*. EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy. Cell Death Dis. 2017 Jun 8;8(6):e2869. doi: 10.1038/cddis.2017.268.

11. Xingwen Wang, Miao Yu, Kunming Zhao, Mengmeng He,Wenjie Ge,Yuhui Sun,Yihua Wang, Haizhu Sun, Ying Hu*. Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. Cell Death Dis. 2016 Dec 8;7(12):e2517. doi: 10.1038/cddis.2016.412.

12. L.N. Shao，S. T. Zhang，W. J. Yu，S. H. Zhou，Y. Duan，L. Z. Pan，N. Wang，Ying Hu*，HLA-A, HLA-B, HLA-DRB1 allele and haplotype frequencies of 14,529 Chinese Han bone marrow donors living in Dalian, China.，International Journal of Immunogenetics DOI:10.1111/iji.12248, 2016 Apr;43(2):79-85.doi: 10.1111/iji.12248. Epub 2016 Feb 5.

13. Sun H, Ge W,Gao X, Wang S, Jiang S, Ying Hu*, Yu M* , Hu S*. Apoptosis- Promoting Effects of Hematoporphyrin Monomethyl Ether- Sonodynamic Therapy (HMME-SDT) on Endometrial Cancer. PLoS One. 2015 Sep 14;10(9):e0137980.

14. Zinaida Dedeic#, Gopinath Sutendra#, Ying Hu#, Kathryn Ho Ki Chung, Elizabeth A. Slee, Michael J. White, Felix Zhou, Robert D. Goldin, David J. P. Ferguson, Debra McAndrew, Jurgen E. Schneider and Xin Lu. Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders. Cell Death and Differentiation, 2018 Jul;25(7):1289-1303.

15. Mario Notari#，Ying Hu#，Sofia Koch，Min Lu， Indrika Ratnayaka，Shan Zhong，Caroline Baer，Anna Pagotto，Robert Goldin，Victoria Salter，Eleonora Candi，Gerry Melino，and Xin Lu*. iASPP prevents premature cellular senescence and is required for normal epithelial stratification. Proc Natl Acad Sci. 2011. 108(40): 16645–16650.

16. Ying Hu，Elizabeth Pang，Paul B.-S. Lai，Jeremy A. Squire，Pascale F. MacGregor，Ben Beheshti，Monique Albert，Thomas W.-T. Leung，Nathalie Wong*，Genetic alterations in doxorubicin-resistant hepatocellular carcinoma cells: a combined study of spectral karyotyping, positional expression profiling and candidate genes.，Int J Oncol，2004.11.1，25（5）：1357~1364.

開(kāi)設的課程

生物統計學(xué)

Biostatistics

生物學(xué)基礎與應用

Biological Basis and Application

腫瘤生物學(xué)進(jìn)展前沿

Progress and Frontiers in Cancer Research

教師個(gè)人主頁(yè)鏈接

http://homepage.hit.edu.cn/huying